Correlation analysis of metabolically healthy obesity and erectile dysfunction: a cross-sectional… — The aging male : the official journal of the International Society for the Study of the Aging Male (2026)
Identificação
Seção intitulada “Identificação”- PMID: 42537115
- DOI: 10.1080/13685538.2026.2712119
- Autores: Yuchao Hou, Guangcai Yu, Chengyu Zhang, Jinhui Liu, Rui Li, Benzheng Zhou
- Revista: The aging male : the official journal of the International Society for the Study of the Aging Male
Resumo clínico (PT)
Seção intitulada “Resumo clínico (PT)”Resumo em português pendente de revisão editorial. Configure OPENAI_API_KEY para geração automática ou edite manualmente.
Abstract (original)
Seção intitulada “Abstract (original)”To explore the relationship between metabolically healthy obesity (MHO) and erectile dysfunction (ED). Using National Health and Nutrition Examination Survey (NHANES) data from 2001 to 2004, 974 participants were classified into ED and non-ED groups. MHO diagnosis combined BMI-based obesity assessment with metabolic status evaluation per National Cholesterol Education Program-Adult Treatment Panel III (ATP III) criteria. Weighted univariate and multivariate logistic regression models assessed the association between obesity subtypes and ED. Subgroup analyzes examined association stability across populations. Two-sample Mendelian randomization (MR) evaluated causal relationships between individual metabolic syndrome criteria and ED occurrence. In the optimized model, MHO was not associated with significantly increased ED risk compared to non-obese individuals. Metabolically abnormal obesity was associated with a 13% higher ED risk versus non-obese individuals (OR = 1.13, 95% CI: 1.02-1.25, p = 0.019). Subgroup analyzes showed no significant effect modification across subgroups ( p > 0.05). Combined BMI and metabolic indicators demonstrated stronger predictive ability for ED than BMI alone, with waist circumference showing the strongest individual correlation ( p = 0.001). MHO does not confer elevated ED risk. Metabolically abnormal obesity is associated with a 14% increased ED risk compared to non-obese individuals.